The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicity
Abstract The tumor suppressor PTEN (phosphatase and tensin homolog deleted in chromosome 10) is genetically deleted or downregulated in many Poker cancer types.Loss of PTEN protein expression is frequently found in lung cancer while genetic alterations are less abundant.PTEN expression is regulated at multiple genetic and epigenetic levels and even